Research

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Highlighted

Single-cell lysis patterns morphogenesis of eDNA in the matrix of Pseudomonas aeruginosa biofilms

Georgia R. Squyres, Dianne K. Newman

Proceedings of the National Academy of Sciences  ·  06 Oct 2025  ·  10.1073/pnas.2514210122

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2026

Starvation enhances bacterial survival through drying and rewetting at the single cell level

Jarek V. Kwiecinski, Georgia R. Squyres, Dani Or, Dianne K. Newman

openRxiv  ·  12 Jan 2026  ·  doi:10.64898/2026.01.12.697931

2025

Single-cell lysis patterns morphogenesis of eDNA in the matrix of Pseudomonas aeruginosa biofilms

Georgia R. Squyres, Dianne K. Newman

Proceedings of the National Academy of Sciences  ·  06 Oct 2025  ·  10.1073/pnas.2514210122

Single-cell lysis patterns morphogenesis of eDNA in the matrix of Pseudomonas aeruginosa biofilms

Georgia R. Squyres, Dianne K. Newman

Proceedings of the National Academy of Sciences  ·  06 Oct 2025  ·  doi:10.1073/pnas.2514210122

Extracellular matrix chemistry tunes bacterial biofilm metabolism and optimizes fitness

Jinyang Li, Georgia R. Squyres, Kathy Duong, Courtney Reichhardt, Matthew R. Parsek, Dianne K. Newman

openRxiv  ·  18 Sep 2025  ·  doi:10.1101/2025.09.18.677115

SpoIIE drives asymmetric cell division in B. subtilis by sequential modulation of the cytokinesis machinery

Alexis Ryan, Georgia R. Squyres, Matthew J. Holmes, Alex Bisson, Ethan C. Garner, Niels Bradshaw

openRxiv  ·  10 Jun 2025  ·  doi:10.1101/2025.06.09.658746

2024

Biofilms as more than the sum of their parts: lessons from developmental biology

Georgia R Squyres, Dianne K Newman

Current Opinion in Microbiology  ·  01 Dec 2024  ·  doi:10.1016/j.mib.2024.102537

Cell constriction requires processive septal peptidoglycan synthase movement independent of FtsZ treadmilling in Staphylococcus aureus

Simon Schäper, António D. Brito, Bruno M. Saraiva, Georgia R. Squyres, Matthew J. Holmes, Ethan C. Garner, Zach Hensel, Ricardo Henriques, Mariana G. Pinho

Nature Microbiology  ·  13 Mar 2024  ·  doi:10.1038/s41564-024-01629-6

2023

Mycobacterial nucleoid-associated protein Lsr2 is required for productive mycobacteriophage infection

Charles L. Dulberger, Carlos A. Guerrero-Bustamante, Siân V. Owen, Sean Wilson, Michael G. Wuo, …, Michael Baym, Laura L. Kiessling, Ethan C. Garner, Eric J. Rubin, Graham F. Hatfull

Nature Microbiology  ·  23 Feb 2023  ·  doi:10.1038/s41564-023-01333-x

2021

Designing efficient genetic code expansion in Bacillus subtilis to gain biological insights

Devon A. Stork, Georgia R. Squyres, Erkin Kuru, Katarzyna A. Gromek, Jonathan Rittichier, Aditya Jog, Briana M. Burton, George M. Church, Ethan C. Garner, Aditya M. Kunjapur

Nature Communications  ·  14 Sep 2021  ·  doi:10.1038/s41467-021-25691-4

Single-molecule imaging reveals that Z-ring condensation is essential for cell division in Bacillus subtilis

Georgia R. Squyres, Matthew J. Holmes, Sarah R. Barger, Betheney R. Pennycook, Joel Ryan, Victoria T. Yan, Ethan C. Garner

Nature Microbiology  ·  18 Mar 2021  ·  doi:10.1038/s41564-021-00878-z

Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism

Joshua W. McCausland, Xinxing Yang, Georgia R. Squyres, Zhixin Lyu, Kevin E. Bruce, …, Bill Söderström, Ethan C. Garner, Malcolm E. Winkler, Jie Xiao, Jian Liu

Nature Communications  ·  27 Jan 2021  ·  doi:10.1038/s41467-020-20873-y

2018

A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery

Patricia D. A. Rohs, Jackson Buss, Sue I. Sim, Georgia R. Squyres, Veerasak Srisuknimit, …, Andrew C. Kruse, Ethan C. Garner, Suzanne Walker, Daniel E. Kahne, Thomas G. Bernhardt

PLOS Genetics  ·  18 Oct 2018  ·  doi:10.1371/journal.pgen.1007726

2017

Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division

Alexandre W. Bisson-Filho, Yen-Pang Hsu, Georgia R. Squyres, Erkin Kuru, Fabai Wu, …, Cees Dekker, Seamus Holden, Michael S. VanNieuwenhze, Yves V. Brun, Ethan C. Garner

Science  ·  17 Feb 2017  ·  doi:10.1126/science.aak9973

2015

Facultative Control of Matrix Production Optimizes Competitive Fitness in Pseudomonas aeruginosa PA14 Biofilm Models

Jonas S. Madsen, Yu-Cheng Lin, Georgia R. Squyres, Alexa Price-Whelan, Ana de Santiago Torio, Angela Song, William C. Cornell, Søren J. Sørensen, Joao B. Xavier, Lars E. P. Dietrich

Applied and Environmental Microbiology  ·  15 Dec 2015  ·  doi:10.1128/AEM.02628-15